Molecular Markers of Resistance to Drugs in Parasitic Infections

Recent developments in research into the Cyathostominae and Anoplocephala perfoliata.

Intestinal helminths are an important cause of equine disease...
Source: Vet. Res. 35(4): 371-81
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Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.

Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with specific point mutations in the pfcrt and pfmdr-1 genes...
Source: Ann Trop Med Parasitol 2003 Jul; 97(5): 439-51
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21 Apr 2003

CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response.

Leishmania, a protozoan parasite, lives and multiplies as amastigote within macrophages...
Source: J. Exp. Med. 2003 Apr; 197(8): 1037-43
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1 Mar 2003

Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.

The clinical significance of cytomegalovirus (CMV) foscarnet resistance was studied in patients with acquired immunodeficiency syndrome and CMV retinitis...
Source: J. Infect. Dis. 2003 Mar; 187(5): 777-84
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Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi.

Innate immunity as a first defense is indispensable for host survival against infectious agents...
Source: Infect. Immun. 2003 Mar; 71(3): 1234-41
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Use of nested PCR for differential diagnosis of falciparum malaria reinfection and relapse in drug-resistant patients.

Microscopic examination does not allow differentiation of drug-resistant P...
Source: Bull. Exp. Biol. Med. 2002 Oct; 134(4): 379-81
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Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes.

The benznidazole (BZ) and itraconazole (ITC) susceptibilities of a standard set of Trypanosoma cruzi natural stocks were evaluated during the acute phase and the chronic phase of experimental chagasic infection in BALB/c mice...
Source: Antimicrob. Agents Chemother. 2003 Jan; 47(1): 223-30
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Molecular epidemiology of malaria in Cameroon. XIV. Plasmodium falciparum chloroquine resistance transporter (PFCRT) gene sequences of isolates before and after chloroquine treatment.

Laboratory studies have strongly suggested that the gene coding for Plasmodium falciparum chloroquine resistance transporter (PFCRT) may play a determinant role in chloroquine resistance...
Source: Am. J. Trop. Med. Hyg. 2002 Oct; 67(4): 392-5
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Oral fungal and bacterial infections in HIV-infected individuals: an overview in Africa.

Oral opportunistic infections developing secondary to human immunodeficiency virus (HIV) infection have been reported from the early days of the epidemic and have been classified by both the EC-Clearinghouse and the World Health Organisation (WHO)...
Source: Oral Dis 2002 8 Suppl 2: 80-7
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Antibody isotype responses to Schistosoma japonicum antigens in subjects from a schistosomiasis area with repeated praziquantel chemotherapy compared with a new endemic zone in Hunan Province, P.R. China.

To demonstrate the dynamics of specific antibody isotypes against schistosome adult worm (AWA) and soluble egg (SEA) antigens, we evaluated (in 1999-2000) 112 subjects infected with Schistosoma japonicum from 2 regions of Hunan Province, China...
Source: Trans. R. Soc. Trop. Med. Hyg. 96(2): 210-5
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