Molecular Markers of Resistance to Drugs in Parasitic Infections

15 Aug 2010

Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni.

BACKGROUND: Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence...
Source: J. Infect. Dis. 2010 Aug; 202(3): 399-405
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A microsimulation of the cost-effectiveness of maraviroc for antiretroviral treatment-experienced HIV-infected individuals.

PURPOSE: Maraviroc (MVC) is the first approved CCR5 antagonist...
Source: HIV Clin Trials 11(2): 80-99
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Active case detection, treatment of falciparum malaria with combined chloroquine and sulphadoxine/pyrimethamine and vivax malaria with chloroquine and molecular markers of anti-malarial resistance in the Republic of Vanuatu.

BACKGROUND: Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s...
Source: Malar. J. 2010 9(1): 89
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Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy.

BACKGROUND: The efficacy of amodiaquine (AQ), sulphadoxine-pyrimethamine (SP) and the combination of SP+AQ in the treatment of Cameroonian children with clinical malaria was investigated...
Source: Malar. J. 2010 9: 34
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Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance.

BACKGROUND: Molecular monitoring of parasite resistance has become an important complementary tool in establishing rational anti-malarial drug policies...
Source: Malar. J. 2010 9: 8
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[ANRS-fibrovic and homavic: role of non invasive markers of liver fibrosis and insulin resistance during antiviral treatment in HIV-HCV co-infected patients from ANRS HC 02 RIVABIC trial]

Non invasive liver fibrosis scores have been proposed as alternatives to liver biopsy in hepatitis C virus (HCV) -infected patients...
Source: Gastroenterol. Clin. Biol. 2009 Mar; 33 Suppl 2: S113-7
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CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.

Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions...
Source: Hum. Immunol. 2009 Apr; 70(4): 244-50
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16 Sep 2009

A survey on meat sheep farms in two regions of Morocco on farm structure and the acceptability of the targeted selective treatment approach to worm control.

Sheep production is very important in Morocco and two regions (Chaouia plain and semi-mountainous Middle-Atlas) play a significant role in this production...
Source: Vet. Parasitol. 2009 Sep; 164(1): 30-5
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[At what time and with which combinations should maraviroc be indicated in the new antiretroviral treatment scenario?]

Maraviroc is a selective and slowly reversible antagonist of the CCR5 co-receptor which has shown to have powerful antiviral activity, in vitro, against a wide range of HIV clinical isolates, including strains multi-resistant to 4 classes of pre-existing antiretroviral drugs...
Source: Enferm. Infecc. Microbiol. Clin. 2008 Oct; 26 Suppl 11: 34-9
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1 Apr 2009

Evaluation of Plasmodium vivax genotyping markers for molecular monitoring in clinical trials.

BACKGROUND: Many antimalarial interventions are accompanied by molecular monitoring of parasite infections, and a number of molecular typing techniques based on different polymorphic marker genes are used...
Source: J. Infect. Dis. 2009 Apr; 199(7): 1074-80
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